2024 He made his senior debut in 2021 and was a key member of the squads that won the 2021 Copa América, 2022 FIFA World Cup, and 2024 Copa América.
2024 After a successful loan spell, Romero was signed by Tottenham in 2022, and went on to win the 2024–25 UEFA Europa League.
2020 After being named Serie A's Best Defender for the 2020–21 season, the club exercised the option of purchase, before promptly loaning Romero to Tottenham with an obligation to buy.
2017 Romero represented Argentina at the youth level at the 2017 South American U-20 Championship.